The United States Swine Pathogen Database (US-SPD)
The genetic and antigenic diversity of viruses that currently circulate in swine continues to increase: this poses a challenge for producers, as established vaccination and other control measures are unlikely to work. In addition, novel viruses appear to periodically emerge in swine populations (e.g., Senecavirus A, Porcine epidemic diarrhea virus) which can led to establishment and persistence of antigenically distinct viruses that do not have appropriate vaccines because there is limited information from which to derive rational formulations. Thus, given that the genetic makeup of viruses continually changes, monitoring the patterns of genetic change of viruses in swine is needed to identify possible emerging threats and also help control endemic viruses.
This database aids in improving agricultural production and preparedness for novel and endemic swine pathogens by allowing for the identification of important changes in genetic diversity and provides a benchmark from which to measure success of intervention strategies. These interventions include timely vaccine and diagnostic updates for use in swine, as well as factors to prevent infection and transmission, such as changes in production practices, farm management, and vaccine implementation.
|22-Apr-2021||bioRxiv preprint (doi: 2021.04.16.439882) describing the US-SPD released.|
|30-Mar-2021||Addition of complete genome annotation tool. All US-SPD services have been made public.|
|01-Mar-2021||New announcement and database update tracking feature for the US-SPD project|