Porcine sapelovirus (PSV) is a positive-sense RNA virus approximately 7.5–8.3 kb in length that is classified into the genus Sapelovirus under the family Picornaviridae. Generally, PSV infections are asymptotic but are also associated with encephalomyelitis, respiratory distress, fertility disorders and skin lesions. PSV-associated outbreaks have been reported where death occurs due to polioencephalitis and respiratory paralysis. PSV has been detected worldwide, with moderate-to-high prevalence and clinical course observed in several European and Asian countries. The virus is highly stable in different environmental conditions and spreads readily via faeco-oral route.