Transmissible gastroenteritis virus (TGEV) is an enveloped, positive-sense, single-stranded RNA virus approximately 28.5 kb in length belonging to the genus Alphacoronavirus of the Orthocoronavirinae subfamily in the Coronaviridae family. TGEV was first described in 1946 in the USA and has since been detected throughout the world. TGEV transmits via the ingestion of contaminated feces or nasal secretions. Clinical symptoms include vomiting, watery diarrhea, dehydration, and weight loss. Mortality rate can exceed 90% and is inversely related to the age of pigs. The prevalence of TGEV has declined sharply as a natural mutant, Porcine respiratory coronavirus (PRCoV), presumably stimulates immunity to TGEV.
Notice: PRCoV shares the same species name as TGEV and has high genetic similarity. However, there are few to no commonalities in epidemiology, pathogenesis, and clinical signs. TGEV and PRCoV will be differentiated whenever possible, but in the event classification is uncertain, the sample will be labeled as TGEV by default.