Porcine epidemic diarrhea virus (PEDV) is a member of the Coronaviridae family and is an enveloped, single-stranded, positive-sense RNA virus. The genome is approximately 28 kb and encodes non-structural proteins and four major structural proteins including spike, envelope, membrane, and nucleocapsid proteins (see Song and Park, 2012).
First isolated in 1978 in Belgium, PEDV is widespread in Europe and Asia and has recently become endemic in North America following initial detection in Indiana, USA in May 2013 and in Canada in the winter of 2014. The main method of PEDV transmission is fecal-oral. Clinical symptoms of PEDV infection include vomiting, watery diarrhea, dehydration, and weight loss. PEDV causes significant morbidity and mortality with dramatic production and economic consequences.